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Zebrafish models are gaining recognition in their applications within several fields, such as developmental biology and toxicology. The advantages of the zebrafish model are mainly its low cost and ease of maintenance and breeding. Moreover, the zebrafish is ideal for research purposes due to its small size, ease of handling and transparency. Integrating the use of fluorescent reporter genes into the zebrafish model allows the visualization of specific tissues, such as the liver.

Drug-induced hepatotoxicity is one of the most important causes of drug withdrawal in the process of Drug Discovery. The low correlation of the in vitro cytotoxicity studies with human hepatotoxicity, especially in the early stages of Drug Development, makes human hepatotoxicity difficult to predict. Therefore, new methods and models to predict hepatotoxicity are needed. Mechanisms that occur during the Development process have been characterized, leading to an important knowledge about the signaling pathways that govern zebrafish liver function.

Vendor: Biobide